WHEN THE BODY LOSES ITS FITRAH
You may have spent years caring for everyone around you — your family, your work, your responsibilities and the people who depend on you. In the name of love and responsibility, it is easy to give away pieces of yourself quietly: your sleep, your time, your energy and sometimes even the attention your own health has been asking for.
Cancer makes this truth especially profound. It may begin with abnormal cells and tissues, but its impact rarely stays there. It can change the rhythm of a family, disturb sleep, reshape emotions, challenge confidence and alter the way a person imagines tomorrow. The medical condition may be located in the body, but the experience belongs to the whole human being. Yet illness does not diminish human worth. A person living with gallbladder cancer remains worthy of tenderness, dignity, attention and care. This leads us to a deeper question: What happens when the natural order that helps the body maintain balance begins to change?
At Ibnu Sina Wellness, this is where we begin looking beyond one diagnosis. We model the fundamentals of Ibnu Sina’s medical philosophy through a contemporary whole-person framework that considers the BODY-HEART-MIND-SOUL. [1] The body is not a collection of isolated parts. The human body functions as one connected living system, connected to the environment and way of life.
BUT WHY DOES CANCER OCCUR?
After a cancer diagnosis, one question can become difficult to escape: “Why did this happen?” Cancer is a complex group of diseases in which abnormal cells can grow beyond their usual boundaries and, in some cancers, invade surrounding tissues or spread to other parts of the body. Cancer develops through interactions between cellular changes and multiple biological, environmental and lifestyle influences. [2] But cells do not live in isolation. They exist within tissues containing blood vessels, immune cells, structural components and chemical signals. These relationships form part of the biological environment in which normal tissue — and cancer — develops.
Inflammation is one example. It is normally part of the body’s protective response. But when inflammatory activity remains active over a prolonged period, it can contribute to tissue dysfunction and biological processes associated with long-term disease, including cancer. [4] This gives us a more useful way to think about cancer. Cancer is not simply a lump that suddenly appeared. It is a complex disease occurring within an equally complex human body. And therefore we ask: How do we understand the condition of the whole system rather than looking only at the place where the disease becomes visible?
WHAT MAKES GALLBLADDER CANCER DIFFERENT?
The gallbladder is a small organ located beneath the liver. Its main role is to store and concentrate bile produced by the liver and release it into the digestive tract when needed, particularly during the digestion of dietary fat. The gallbladder belongs to the wider biliary system, which includes the liver and bile ducts. Gallbladder cancer is therefore closely connected anatomically and functionally with structures involved in digestion and bile flow. [3] Most gallbladder cancers are adenocarcinomas, meaning that they arise from gland-forming epithelial cells lining the gallbladder. Other pathological forms can occur, but they are much less common. [6]
One of the most important characteristics of gallbladder cancer is that it can be difficult to recognise early. The gallbladder lies deep within the upper abdomen, and early disease may produce few obvious symptoms. Some gallbladder cancers are discovered incidentally when the gallbladder is removed for what was thought to be a benign condition, such as gallstone disease. [7] This incidental discovery is clinically important. A person may undergo cholecystectomy expecting treatment for gallstones or another non-cancerous gallbladder problem, only for pathological examination of the removed tissue to reveal cancer. [7]
When symptoms do occur, they may include pain or discomfort in the upper abdomen, jaundice, nausea, vomiting, reduced appetite, abdominal swelling or other digestive changes. Some people may also experience unexplained weight loss or general decline in wellbeing. [6] These symptoms can occur for many reasons other than cancer. Their presence does not automatically mean gallbladder cancer. But persistent, unexplained or worsening changes deserve appropriate medical assessment. Risk also develops within a particular biological context.
Gallstones are one of the most important recognised conditions associated with gallbladder cancer. Chronic irritation and inflammation associated with gallstone disease form part of the biological pathway studied in relation to malignant transformation within the gallbladder. [6] Obesity has also been associated with increased risk of several cancers, including gallbladder cancer. [13] This does not mean that every person with gallstones or obesity will develop gallbladder cancer.
Most people with gallstones do not develop cancer. Risk factors describe increased probability. They do not determine an individual’s future, and they should never be used to blame the person living with disease. At the molecular level, gallbladder cancer is also biologically complex. Contemporary research is revealing substantial differences between malignant cells and their surrounding immune and stromal environment. Single-cell analysis has demonstrated important microenvironmental changes during the development of gallbladder cancer. [5] Understanding these disease-specific features matters.
But the gallbladder still belongs to a living person whose liver, digestive system, metabolism, physical health, emotions, thoughts, relationships, responsibilities and spiritual wellbeing continue alongside the diagnosis. The tumour matters. But so does the person living through everything around it.
WHAT DID IBNU SINA UNDERSTAND ABOUT HEALTH AND DISEASE?
Ibnu Sina — also known as Avicenna — wrote more than 450 books including Al-Qanun fi al-Tibb, or The Canon of Medicine. His medical writings reflected the knowledge and medical framework beyond his historical period, including the humoral theory — a model that explained health through the balance of bodily humours or fluids. [8] An important principle within Ibnu Sina’s medical reasoning remains deeply relevant to the philosophy of Ibnu Sina Wellness: do not understand one part of ailment without understanding the condition of the whole person. [1] At Ibnu Sina Wellness, we have taken inspiration from this whole-person orientation and developed it into a contemporary framework.
The disease may appear in one organ. But the person experiencing it is always more than that one organ.
IBNU SINA WELLNESS — MODELING THE FUNDAMENTALS OF IBNU SINA MEDICINE
Ibnu Sina Wellness was established in 2015 in Kajang, Selangor, Malaysia. Since then, our work has focused on bringing whole-person principles into a structured wellness model. We have served people from Malaysia, Singapore, Indonesia and Brunei, including people living with complex and long-standing health challenges. Through that experience, one principle has remained central to our philosophy: We do not reduce a person to a diagnosis. We want to understand the whole human being.
THE BPS-S LENS VIEWS THE PERSON BEHIND THE DIAGNOSIS
This is where the Biopsychosocial-Spiritual, or BPS-S, framework becomes especially important. BPS-S recognises that human health and illness are experienced across interconnected biological, psychological, social and spiritual dimensions. These dimensions do not exist as separate compartments. They belong to one human life. [1] For someone living with gallbladder cancer, the biological dimension may include pain, digestive symptoms, jaundice, changes in appetite or nutrition, physical weakness, sleep, treatment effects and the wider functions of the liver and biliary system.
The psychological dimension includes fear, uncertainty, thoughts, beliefs, coping and the emotional impact of receiving a diagnosis that may sometimes be discovered unexpectedly. The social dimension includes family, relationships, caregiving, work, finances, appointments, support systems and the practical changes that illness can bring into everyday life. The spiritual dimension includes meaning, hope, purpose, relationship with Allah and the way a person understands illness within the wider journey of life. These dimensions interact. Physical symptoms may influence appetite and energy. Reduced physical capacity may alter family roles.
Whole-person care therefore creates space to understand not only the biological condition, but also what the person is carrying emotionally, socially and spiritually. [9] Uncertainty may affect sleep. Treatment and repeated healthcare visits can affect daily routines and relationships. Research in advanced gallbladder cancer has also explored structured palliative-care interventions aimed at supporting functional recovery, resilience and quality of life. [10] This reminds us that caring for someone with gallbladder cancer involves more than measuring the tumour. A diagnosis tells us what disease is present. It does not tell us everything the person is carrying.
To care for the person well, we must first learn to see the person as a whole.
AT IBNU SINA WELLNESS, WE DO NOT LOOK AT ONLY ONE DISEASE
When someone comes to us with gallbladder cancer, we do not want to see only the words written on a medical report. We want to see:
THE WHOLE PERSON.
Within the Ibnu Sina Wellness functional framework, body functions are mapped across:
12 MAJOR BODY SYSTEMS
and
120 MICRO-SYSTEMS.
The 120 Micro-Systems are an Ibnu Sina Wellness functional framework. They give our practitioners and educators a more detailed way of asking: “Where is the body’s function giving us a signal?” Instead of seeing one disease in one organ, we look at the interconnected network supporting the person.
THE 12 SYSTEMS ARE NOT 12 SEPARATE MACHINES
The human body is made up of systems with different responsibilities, but they do not function like twelve separate machines. The nervous system communicates and coordinates. The endocrine system regulates through hormones. The cardiovascular system circulates blood, oxygen and nutrients, while the respiratory system performs the essential exchange of gases. The digestive system processes and absorbs what we eat, the liver carries out vital metabolic and processing functions, and the urinary system regulates fluids while eliminating metabolic waste. [11]
The same interdependence continues throughout the body. The immune system protects and monitors, the lymphatic system supports immune function and fluid balance, the musculoskeletal system provides structure and movement, the integumentary system — the skin, hair, nails and associated structures — protects the body while interacting with the external environment, and the reproductive system carries reproductive and hormonal functions. [11] The gallbladder itself demonstrates this connection. It stores bile produced by the liver and releases it through the biliary pathways into the intestine as part of digestion.
Disease affecting the gallbladder therefore exists within a wider anatomical and functional network that includes the liver, bile ducts, digestive tract, circulation and surrounding tissues. [3] But none of these systems operates independently. Hormones travel through the circulation. The lungs and cardiovascular system work together to deliver oxygen. The kidneys regulate fluids and electrolytes. The nervous and endocrine systems coordinate countless processes throughout the body. [11] The body works through connection. And that is why understanding one part often requires us to look at the system surrounding it.
THE 120 MICRO-SYSTEMS AS CHECKPOINTS
This is where our 120 Micro-Systems become particularly important. Rather than beginning only with the question, “What disease do you have?”, we begin by looking more closely at the signals the body is giving us. Which system is signalling that something has changed? Which micro-system may be involved? What function is being affected? What may be disturbing that function? And what root-cause factors may need to be explored? This creates a pathway for deeper investigation: Symptom → System → Micro-System → Function → Imbalance → Root-Cause Factors → Restoration of Balance
The purpose is to move beyond naming the symptom and stopping there. A symptom can tell us where to begin looking, but it does not necessarily tell us the whole story. The symptom is not the end of the investigation. It is the beginning.
WHY THE MICRO-SYSTEM CANNOT BE SEPARATED FROM THE WHOLE PERSON
There is another principle that is essential: a micro-system does not exist separately from the life of the person experiencing the problem. A biological function may be under strain, while the same person may also be experiencing fear, anxiety, grief, anger, uncertainty, disturbed sleep, changes in relationships, loss of confidence, caregiving demands or spiritual distress. For someone living with gallbladder cancer, the questions may include: Why was it not discovered earlier? Will I be able to eat normally? What happens if the disease has already spread? How will my family cope? What comes next?
These questions belong to the person experiencing the disease. So when we say “we look at the micro-system,” we are not looking only at biology. The BPS-S perspective helps us understand how these dimensions exist within the same life. What happens in the body is experienced by a person who also has emotions, thoughts, relationships, responsibilities and a spiritual life. [1] So when we say “we look at the micro-system,” we are not looking only at biology. We are also asking what is happening emotionally and mentally, what is happening within relationships and circumstances, and what is happening within the spiritual dimension of life. Because these are not separate human beings.
They are dimensions of one human life. And that is why understanding the micro-system must always lead us back to understanding the whole person.
THE MICRO-SYSTEM IS A BIOLOGICAL CHECKPOINT — BUT THE PERSON IS MORE THAN BIOLOGY
Imagine a city. You cannot understand its condition by looking at one building alone. Roads, water systems, electricity, communication networks, transportation, waste management, security and emergency services all depend upon smaller functions working together. The human body is far more complex. Every major system contains specialised functions, and those functions continuously interact with others. But the human being adds another layer: the person living inside that body has emotions, thoughts, relationships, memories, responsibilities, values and a spiritual life. [9] The physical condition is real. But so is the person experiencing it.
A biological checkpoint can help us understand what is happening within the body, but it can never describe the whole human being.
WHAT DOES “TOXIC BURDEN” MEAN AT IBNU SINA WELLNESS?
One of the concepts we investigate at Ibnu Sina Wellness is toxic burden. This can include harmful exposures associated with cancer risk, such as tobacco smoke, alcohol, air pollution, ultraviolet and ionising radiation, cancer-causing infections and particular occupational or environmental carcinogens. [2] [12] We also look at the wider metabolic and lifestyle environment surrounding the individual. Excess body weight, physical inactivity and patterns of nutrition are among the modifiable factors studied in relation to cancer risk, while chronic inflammation forms part of the wider biological environment relevant to disease. [4] [12]
Sleep and prolonged stress matter here for a different but equally human reason. They shape the way a person functions, copes and moves through illness, and therefore belong within the wider whole-person picture. [1] [10] This can include harmful exposures associated with cancer risk, such as tobacco smoke, alcohol, air pollution, ionising radiation, cancer-causing infections and particular occupational or environmental carcinogens. [2] [12] However, not every exposure is relevant to every cancer. And we should not take general cancer risk factors and automatically claim that they caused one person’s gallbladder cancer. For gallbladder cancer, disease-specific factors matter.
Gallstone disease is particularly important. Long-standing gallstones and the chronic inflammatory environment that can accompany them are strongly associated with gallbladder cancer risk. [6] Obesity is another factor associated with increased gallbladder cancer risk and belongs within the wider metabolic risk landscape. [13] These associations do not mean that one exposure explains every individual diagnosis. Cancer remains biologically complex.
We also look at the wider environment surrounding the person — including nutrition, movement, sleep, body composition and avoidable harmful exposures — because these factors matter to general health and physiological resilience even when they cannot be presented as direct causes of a particular cancer. Chronic inflammation forms part of the wider biological environment relevant to long-term disease. [4] Sleep and prolonged stress matter for another reason. They affect how a person functions, copes and moves through illness. They should not be presented as proven direct causes of gallbladder cancer.
Toxic burden is therefore not one mysterious substance. It is not a claim that one toxin explains gallbladder cancer. It is a wider way of examining avoidable harmful exposures and unnecessary burdens while respecting what disease-specific science actually shows. At Ibnu Sina Wellness, we bring these pieces together to understand the wider pattern of exposures, physiological demands and modifiable burdens surrounding the person. The body does not experience life as a list of separate risk factors. It experiences the pattern created by them over time.
Toxic burden is therefore not one substance. It is the cumulative pattern of what the body has repeatedly been asked to process, tolerate and adapt to over time.
THE BIOLOGICAL BURDEN AND THE EMOTIONAL-MENTAL-SOUL BURDEN
A person may carry biological burdens while also carrying grief, fear, anger, betrayal, loneliness or unresolved emotional pain. The mind can carry its own burden too — constant worrying, overthinking, perfectionism, self-criticism, uncertainty or feeling that one must always remain strong. Daily life may add another layer through caregiving responsibilities, financial pressure, relationship conflict, work demands and long periods of uncertainty.
There is also the spiritual dimension. A person may struggle with meaning, hope, spiritual connection, trust in Allah or the feeling that life has lost its direction. Spiritual distress has also been described among people living with cancer. [15] For someone with advanced gallbladder cancer, symptom burden and loss of physical function may further affect independence and quality of life. Research examining palliative-care interventions in advanced gallbladder cancer has specifically considered functional recovery, resilience and quality of life. [10]
There is also the spiritual dimension. A person may struggle with meaning, hope, spiritual connection, trust in Allah or the feeling that life has lost its direction. Spiritual distress has been described among people living with cancer. [15] These experiences should not be described as direct biological causes of gallbladder cancer. They belong instead to the experience of living through illness. This is why the BPS-S perspective matters. The biology matters. But so do the heart, the mind, the life surrounding the person, and the soul.
OVERHAUL BODY™ — SUPPORTS THE WHOLE SYSTEM
This is where Overhaul Body™ fits into the Ibnu Sina Wellness philosophy. Overhaul Body™ is designed as a whole-person journey that looks beyond the tumour to the wider person and the interconnected systems supporting them. Ibnu Sina Wellness offers a new era in cancer healthcare — without chemotherapy, without surgery, without radiation, and without machine-based treatment. Within ISW, its Recovery Plan is structured around 15 integrated methods spanning herbal medicine, mind, natural lifestyle and spiritual care.
This reflects the wider Ibnu Sina Wellness whole-person philosophy, which brings together the body, heart, mind and soul and incorporates approaches such as herbal remedies, natural lifestyle practices, nutrition and spiritual care. [1] This wider supportive view also aligns with the field of integrative oncology, where supportive approaches may be considered alongside cancer-directed care. [17] Within the ISW framework, support begins by strengthening foundations such as nutrition, appropriate movement, bowel movement, sleep, rest and recovery, emotional wellbeing, mental wellbeing and spiritual wellbeing.
Normal physiology itself depends on ongoing processes of regulation and repair. Homeostasis describes the body’s continuous regulation of its internal environment. [11] Tissue repair involves coordinated interactions among cells, signalling molecules and the extracellular matrix as damaged tissue moves towards restoration. [16] These processes remind us of something important: The body is constantly working to regulate, communicate and repair. Our role is to support the person living within that body. And ultimately, the aim of Overhaul Body™ is to support the whole person. We support the body. We support the person. And we leave healing ultimately to Allah.
WHAT DOES “UNLOAD” MEAN?
When we say Overhaul Body™ aims to unload harmful burdens, we mean addressing factors that can reasonably be changed. This may include reducing avoidable harmful exposures, improving nutrition, supporting bowel movement and normal elimination, improving sleep, encouraging appropriate movement, creating space for rest and recovery and addressing emotional, mental and spiritual burdens. For someone living with gallbladder cancer, support also needs to recognise the person’s digestive function, nutritional status, physical capacity and the wider condition of the liver and biliary system. Which systems are under strain? Which burdens may be modifiable?
Sometimes support begins not by adding more, but by asking: What can reasonably be reduced? Because our framework contains 120 Micro-Systems, we can then ask more focused questions: Which functions need attention? Which systems are under strain? Which burdens may be modifiable? What does this person need biologically, psychologically, socially and spiritually? Unloading, in this sense, is about making room for the body and the person to function with less unnecessary burden.
BUT WHAT ABOUT THE CANCER CELL?
Cancer cells involve complex biological changes. They may grow abnormally, escape normal growth controls, interact with surrounding tissue and, in some cancers, invade nearby tissue or spread to other parts of the body. [2] [3] Gallbladder cancer involves complex biological changes. Modern single-cell research shows that malignant cells exist within a complex tumour ecosystem involving immune cells, stromal cells and signalling relationships that can change during cancer development. [5] More recent multi-omic research has further identified distinct tumour microenvironments associated with gallbladder cancer progression. [14] This helps illustrate an important point:
A tumour is not simply an isolated cluster of abnormal cells. It exists within a biological environment. The cancer cell matters. This biology remains important within whole-person care. Within the ISW framework, Overhaul Body™ focuses on supporting the person and the interconnected systems surrounding that biological challenge, while strengthening modifiable foundations across the wider health journey. [1] The cancer cell remains important. But it is not the whole story.
THE LAW OF FITRAH
At Ibnu Sina Wellness, we describe this wider natural order through Fitrah. Fitrah refers to the natural disposition and order created by Allah. Within the ISW BPS-S model, this provides a wider spiritual lens through which health, balance and the human being are understood. [1] At the biological level, the body demonstrates remarkable processes of regulation and repair. When tissues are injured, repair involves coordinated interactions among cells, signalling molecules and the extracellular matrix — the structural material surrounding cells — as the tissue works towards restoration. [16]
The body also continuously regulates temperature, blood glucose, fluid and electrolyte balance, acidity and many other internal conditions. Physiology describes this maintenance of internal stability as homeostasis — the body’s ability to maintain an internal environment compatible with normal function despite changing conditions. [11] When tissues are injured, repair involves coordinated interactions among cells, signalling molecules and the extracellular matrix — the structural material surrounding cells — as tissue moves towards restoration. [16] These are biological processes.
Within the ISW framework, Fitrah gives this natural order a wider meaning. It invites us to recognise that the human body is not merely a machine. It is a living system created with extraordinary organisation by the Almighty Creator. Our responsibility is to support that order as best we can.
THE WHOLE PERSON — NOT ONLY THE CANCER
This brings us to one of the most important principles at Ibnu Sina Wellness: We do not only look at the disease. We look at the body — the physical body and its systems. We look at the heart — emotional wellbeing and the experiences carried within us. We look at the mind — thoughts, perceptions, beliefs and patterns of thinking. And we look at the soul — meaning, purpose, relationship with Allah and spiritual wellbeing. At the same time, the BPS-S lens reminds us to understand the biological, psychological, social and spiritual dimensions together. [1]
Within the body, we look across the 12 body systems and the 120 Micro-Systems as functional checkpoints. This gives us a much richer question than simply asking: “What disease do you have?” We ask: What is your body telling us? Which system is giving the signal? Which functional micro-system may be involved? What is affecting its function? What biological burdens are present? What emotional and mental burdens are present? What is happening in the person’s relationships and circumstances? What is happening in the person’s life and soul? And ultimately: What do we need to understand about the whole you?
COME AND HEAL “ALL” PARTS OF YOU
If you are living with gallbladder cancer and do not know what to do, if the diagnosis was discovered unexpectedly after gallbladder surgery, if you have completed treatment and are now living with uncertainty about what comes next, or if you are experiencing persistent unexplained abdominal symptoms, perhaps what you need is a place where people see more than the diagnosis. Persistent upper abdominal pain, unexplained jaundice, ongoing digestive symptoms or other persistent changes deserve appropriate medical assessment. These symptoms can have many causes other than cancer, but persistent or worsening changes should not simply be ignored. [6] [7]
Come and speak with our professionals. At Ibnu Sina Wellness, established in 2015 in Kajang, Selangor, we welcome you as a whole person. Our multidisciplinary team includes Hakeema, Hakeem, medical doctors, nutrition professionals, physiotherapists and counsellors, working within the broader whole-person philosophy of Ibnu Sina Wellness. And for someone living with gallbladder cancer, we also want to understand how digestion, appetite, nutrition, abdominal symptoms and the wider biliary system may be affecting everyday life.
We want to understand your history, your body, your systems and your 120 functional Micro-Systems. We want to understand your nutrition, movement, bowel movement and sleep, as well as your emotional wellbeing, mental patterns, life circumstances and spiritual wellbeing. We want to understand the person behind the diagnosis. Because what you need now is not another person simply telling you what is wrong with you. We will sit with you to understand the whole you and ask: What has happened to you? What is your body telling us? Which systems need attention? Which burdens can we reduce? How can we support your 120 Micro-Systems?
And how can we help you move towards greater balance and Fitrah? For a consultation, kindly call Ibnu Sina Wellness at 03-604 30663. You may also join Ibnu Sina Wellness Official on TikTok LIVE for general guidance and transform your perspective on daily life issues. You deserve to be cared for as a whole human being. You deserve compassion, dignity and the opportunity to be heard. And you deserve support for the body, heart, mind and soul that have carried you this far. May Allah grant you wellbeing, strengthen your body, calm your heart, illuminate your mind, strengthen your soul and guide you towards what is best for you.
HAKEEMA ROZAINAH
Founder & CEO of Ibnu Sina Wellness
Registered Practitioner with Ministry of Health Malaysia (Act 775 Traditional and Complementary Medicine)
Pioneer of WHO’s Biopsychosocial- spiritual medicine in Malaysia
Specializing in Ibn Sina Medicine, with a focus on herbal therapy for cancer management
Understanding the Whole Person. Discovering the Root. Supporting the Systems. Caring for the 120 Micro-Systems. Returning Towards Fitrah.
REFERENCES
- Hakeema Rozainah, & Prof. Dato Sri Dr. Abu Hassan Asaari. (2025). Biopsychosocial-Spiritual: A New Era in Healthcare. ISW Media Sdn. Bhd.
- World Health Organization. (2023). Cancer fact sheets.
- Søreide, K., Dopazo, C., Berrevoet, F., Carrion-Alvarez, L., Diaz-Nieto, R., Andersson, B., Stättner, S., & joint ESSO-EAHPBA-UEMS core curriculum working group. (2025). Biliary tract cancer. European Journal of Surgical Oncology, 51(6), 108489. doi:10.1016/j.ejso.2024.108489. PMID: 38902180.
- Furman, D., Campisi, J., Verdin, E., et al. (2019). Chronic inflammation in the etiology of disease across the life span. Nature Medicine, 25(12), 1822–1832. doi:10.1038/s41591-019-0675-0.
- He, H., Chen, S., Yu, Y., Fan, Z., Qian, Y., Dong, Y., Song, Y., Zhong, C., Sun, X., Cao, Q., Li, S., Huang, W., Li, W., Zhuang, M., Yang, J., Wang, X., Wang, J., Wu, D., Wang, H., & Wen, W. (2024). Comprehensive single-cell analysis deciphered microenvironmental dynamics and immune regulator olfactomedin 4 in pathogenesis of gallbladder cancer. Gut, 73(9), 1529–1542. doi:10.1136/gutjnl-2023-331773. PMID: 38719336.
- Khandekar, R. V., Newman, N., & Gasalberti, D. P. Brachytherapy, Gallbladder Cancer. [Updated 2025 May 27]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan–. PMID: 40198050.
- Feo, C. F., Ginesu, G. C., Fancellu, A., Perra, T., Ninniri, C., Deiana, G., Scanu, A. M., & Porcu, A. (2022). Current management of incidental gallbladder cancer: A review. International Journal of Surgery, 98, 106234. doi:10.1016/j.ijsu.2022.106234. PMID: 35074510.
- Retsas, S. (2024). Perceptions of Cancer Through the Ages—From Hippocratic Oncology to Precision Cancer Medicine. Biomolecules, 14(11), 1383. doi:10.3390/biom14111383.
- Lynch, J. M., van Driel, M., Meredith, P., Stange, K. C., Getz, L., Reeve, J., Miller, W. L., & Dowrick, C. (2022). The Craft of Generalism: Clinical skills and attitudes for whole person care. Journal of Evaluation in Clinical Practice, 28(6), 1187– 1194. doi:10.1111/jep.13624.
- Rohilla, K. K., Kalyani, C. V., Gupta, A., Gupta, M., & Matella, N. (2023). Effectivity of Palliative Care Bundle on Advanced Gallbladder Cancer: A Randomised Controlled Trial. Indian Journal of Palliative Care, 29(4), 447–455. doi:10.25259/IJPC_33_2023. PMID: 38058481.
- Hall, J. E., & Hall, M. E. (2021). Guyton and Hall Textbook of Medical Physiology (14th ed.). Elsevier.
- Islami, F., Marlow, E. C., Thomson, B., McCullough, M. L., Rumgay, H., Gapstur, S. M., Patel, A. V., Soerjomataram, I., & Jemal, A. (2024). Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, 2019. CA: A Cancer Journal for Clinicians, 74(5), 405–432. doi:10.3322/caac.21858.
- Shen, S., Brown, K. A., Green, A. K., & Iyengar, N. M. (2026). Obesity and Cancer: A Translational Science Review. JAMA, 335(15), 1341–1350. doi:10.1001/jama.2026.1114. PMID: 41801209.
- Zhou, T., Wu, Y., Li, S., Qiu, X., Liu, E., Xie, Z., Shi, X., Zhang, Y., Ma, G., Guo, W., Wang, X., Wang, K., Yao, X., Hu, J., Shen, S., Yang, S., Jiang, X., Fu, J., Wang, H., Gu, J., & Chen, L. (2025). Multi-omic analysis of gallbladder cancer identifies distinct tumor microenvironments associated with disease progression. Nature Genetics, 57(8), 1935–1949. doi:10.1038/s41588-025-02236-9. PMID: 40571730.
- Farahani, A. S., Kerdar, S. H., Ashrafizadeh, H., Büssing, A., Mehrnoush, N., Akbari, M. E., Karami, M., Tajalli, S., Mojen, L. K., & Rassouli, M. (2023). The predictors of spiritual dryness among Iranian cancer patients during the COVID-19 pandemic. Frontiers in Psychology, 13, 1024009. doi:10.3389/fpsyg.2022.1024009.
- Krafts, K. P. (2010). Tissue repair: The hidden drama. Organogenesis, 6(4), 225– 233. doi:10.4161/org.6.4.12555.
- Fuller-Shavel, N., & Krell, J. (2024). Integrative Oncology Approaches to Supporting Immune Checkpoint Inhibitor Treatment of Solid Tumours. Current Oncology Reports, 26(2), 164–174. doi:10.1007/s11912-023-01492-4.
October 27, 2026
